Prepare the pork belly: Remove skin if present and cut into 1.5-inch cubes. Combine brown sugar, paprika, garlic powder, onion powder, black pepper, cayenne, and salt to create dry rub.
Season the meat: Generously coat all sides of pork belly cubes with dry rub mixture. Let rest at room temperature for 30 minutes while smoker preheats.
Smoke the pork belly: Preheat smoker to 250°F. Place seasoned cubes directly on grate with space between each piece. Smoke for 2–2.5 hours, checking internal temperature after 2 hours. Pull when it reaches 195°F.
Prepare the glaze: Whisk together BBQ sauce, honey, melted butter, apple cider vinegar, and hot sauce in a bowl until fully combined.
Braise in glaze: Transfer smoked pork belly cubes to disposable aluminum pan. Pour glaze over meat and toss to coat completely. Cover pan tightly with foil.
Continue cooking: Return covered pan to smoker and cook for 1 hour at 250°F. The glaze will caramelize and penetrate the meat.
Finish uncovered: Remove foil and cook uncovered for final 30 minutes, stirring every 10 minutes until glaze thickens and develops sticky bark.